Absolute risk reduction 3.6% (95% confidence interval 1.4 to 5.8). This means that 36 in every 1000 people using the device avoided a clot by using the device. After excluding people who died before 30 days or those not assessed by ultrasound, 122 (8.5%) of the people in the device group and 174 (12.1%) of the people in the standard care group developed deep vein thrombosis within 30 days. There was a reduction in deep vein thrombosis in those using the device.The study included a cost-effectiveness evaluation from an NHS hospital perspective. Only about a quarter of patients complied fully with the requirement to use the device for one month. The device needed to be worn day and night on both legs however, some people had the sleeves removed for some days. Half of the patients were randomly allocated to standard medical care and the other half to standard care plus intermittent pneumatic compression for 30 days or until they could walk independently or were discharged from hospital. This NIHR-funded trial (CLOTS 3) included 2876 immobile stroke patients within the first three days of their hospital admission in 94 UK hospitals. This trial aimed to find out if whether using intermittent pneumatic compression thigh-length sleeves in stroke patients can reduce the risk of deep vein thrombosis in people with stroke who are unable to walk independently. Other treatments such as elastic compression stockings may not be effective for preventing deep vein thrombosis. Although there are drug treatments they increase the risk of bleeding and may not be safe especially in people with stroke. The risk of deep vein thrombosis may affect 20% of immobile people in the first few weeks of stroke. Every year around 110,000 people have a stroke in England. People with stroke who are admitted to hospital and are immobile for a period of time are at risk of developing deep vein thrombosis which can lead to serious complications including death. Providing information to people with stroke and their carers in the benefits and risk of treatment may help them maintain the treatment for 30 days. Healthcare staff working in UK stroke units may require training in the use of intermittent pneumatic compression devices. The results of this study were used in the 2015 update to the 2010 NICE guideline about the care and treatment of people who are at risk of developing deep vein thrombosis while in hospital. When used on people admitted within three days of an acute stroke, this technique was inexpensive and also appeared to improve survival at six months. This NIHR-funded trial found that using intermittent pneumatic compression sleeves around the legs was effective in preventing deep vein thrombosis in immobile people after a stroke. The views expressed are those of the author(s) and reviewer(s) at the time of publication. This is a plain English summary of an original research article.
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